Reaction Details Report a problem with these data
Target
Non-secretory ribonuclease
Ligand
BDBM173615
Substrate
n/a
Meas. Tech.
Ribonuclease Activity Assay
Temperature
303.15±n/a K
Ki
1.164e+5± 1.46e+4 nM
IC50
1.785e+5± 4.9e+3 nM
Comments
extracted
Citation
Chatzileontiadou, DS; Parmenopoulou, V; Manta, S; Kantsadi, AL; Kylindri, P; Griniezaki, M; Kontopoulou, F; Telopoulou, A; Prokova, H; Panagopoulos, D; Boix, E; Balatsos, NA; Komiotis, D; Leonidas, DD Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg Chem 63:152-65 (2015) [PubMed] Article
More Info.:
Target
Name:
Non-secretory ribonuclease
Synonyms:
EDN | Eosinophil-derived neurotoxin (EDN) | Non-secretory ribonuclease | RNAS2_HUMAN | RNASE2 | RNAse 2 | RNS2
Type:
Protein
Mol. Mass.:
18364.09
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
161
Sequence:
MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
Inhibitor
Name:
BDBM173615
Synonyms:
1-({1-[(2R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (I)
Type:
Small organic molecule
Emp. Form.:
C12H15N5O6
Mol. Mass.:
325.2774
SMILES:
OC[C@H]1O[C@H](C(O)[C@H]1O)n1cc(Cn2ccc(=O)[nH]c2=O)nn1 |r|