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Target
Mitogen-activated protein kinase 1
Ligand
BDBM176674
Substrate
n/a
Meas. Tech.
Fluorescence Quenching Assay
Kd
1500±100 nM
Citation
 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent  US9115122 Publication Date 8/25/2015 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK
Type:
Protein
Mol. Mass.:
41278.65
Organism:
Mus musculus (Mouse)
Description:
P63085
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM176674
Synonyms:
US9115122, 76.3
Type:
Small organic molecule
Emp. Form.:
C13H12N2O3S2
Mol. Mass.:
308.376
SMILES:
NCCN1C(=S)S\C(=C/c2ccc3OCOc3c2)C1=O
Structure:
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