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Target
Mitogen-activated protein kinase 1 [D319N]
Ligand
BDBM176675
Substrate
n/a
Meas. Tech.
Fluorescence Quenching Assay
Kd
18000±2000 nM
Citation
 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent  US9115122 Publication Date 8/25/2015 
Target
Name:
Mitogen-activated protein kinase 1 [D319N]
Synonyms:
ERK2(D319N) | Erk2 | MK01_MOUSE | Mapk | Mapk1 | Prkm1
Type:
n/a
Mol. Mass.:
41278.68
Organism:
Mus musculus (mouse)
Description:
P63085[D319N]
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSNEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM176675
Synonyms:
US9115122, 76.4
Type:
Small organic molecule
Emp. Form.:
C14H16N2O3S2
Mol. Mass.:
324.418
SMILES:
COc1ccc(\C=C2/SC(=S)N(CCN)C2=O)cc1OC
Structure:
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