Reaction Details
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Lysosomal acid glucosylceramidase
Ligand
BDBM175503
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
4.5±n/a
Ki
1660±150 nM
IC50
4000±35 nM
EC50
63000±14100 nM
Comments
extracted
Citation
Wustman, BA Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase US Patent US9119845 Publication Date 9/1/2015 More Info.:
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
Inhibitor
Name:
BDBM175503
Synonyms:
US9119845, 4
Type:
Small organic molecule
Emp. Form.:
C11H21NO3
Mol. Mass.:
215.2893
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6]-[#6@@H](-[#8])-[#6@H](-[#8])-[#6@H]-1-[#6]-[#8] |r|
Structure:
