Reaction Details
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Lysosomal acid glucosylceramidase
Ligand
BDBM175507
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
4.5±n/a
Ki
5260±890 nM
IC50
12700±2140 nM
EC50
11600±2400 nM
Comments
extracted
Citation
Wustman, BA Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase US Patent US9119845 Publication Date 9/1/2015 More Info.:
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
Inhibitor
Name:
BDBM175507
Synonyms:
US9119845, 8
Type:
Small organic molecule
Emp. Form.:
C14H21NO3
Mol. Mass.:
251.3214
SMILES:
Cc1cccc(CN2CC[C@@H](O)[C@H](O)[C@H]2CO)c1 |r|
Structure:
