Reaction Details
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Vascular endothelial growth factor receptor 3 [818-948,1003-1077]
Ligand
BDBM176598
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
7.4±n/a
IC50
240±n/a nM
Comments
extracted
Citation
Holmes, IP; Bergman, Y; Lunniss, GE; Nikac, M; Chol, N; Hemley, CF; Walker, SR; Foitzik, RC; Ganame, D; Lessene, R Selective FAK inhibitors US Patent US9120761 Publication Date 9/1/2015 More Info.:
Target
Name:
Vascular endothelial growth factor receptor 3 [818-948,1003-1077]
Synonyms:
FLT4 | VEGFR3 | VGFR3_HUMAN | modified VEGFR3 cytoplasmic domain
Type:
n/a
Mol. Mass.:
34324.27
Organism:
Homo sapiens (Human)
Description:
P35916[818-948,1003-1077]
Residue:
306
Sequence:
DPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRG
Inhibitor
Name:
BDBM176598
Synonyms:
US9120761, 12
Type:
Small organic molecule
Emp. Form.:
C28H32F3N5O
Mol. Mass.:
511.5818
SMILES:
CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)c(C)c1
Structure:
