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Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [1-175]
Ligand
BDBM50214969
Substrate
n/a
Meas. Tech.
FabZ Inhibition Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
6.1e+3± 1.4e+3 nM
Comments
extracted
Citation
 McGillick, BE; Kumaran, D; Vieni, C; Swaminathan, S ß-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies. Biochemistry 55:1091-9 (2016) [PubMed]  Article 
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [1-175]
Synonyms:
FABZ_YERPY | beta-Hydroxyacyl-acyl carrier protein dehydratase (YpFabZ) | fabZ
Type:
Protein
Mol. Mass.:
19543.64
Organism:
Yersinia pestis
Description:
B1JQH1[1-175]
Residue:
175
Sequence:
MTTDTHTLHIEEILDLLPHRFPFLLVDRVLDFEEGKFLRAVKNVSFNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSRGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVEFVKERRGLTRFTGVAKVDGEIVCTATMMCARSKPAAPAESVVVKPDVVKPDVVNPVVKE
  
Inhibitor
Name:
BDBM50214969
Synonyms:
1,3,6-Trihydroxy-7-methoxy-2,8-bis-(3-methyl-but-2-enyl)-xanthen-9-one | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone | CHEMBL323197 | Mangostin | alpha-mangostin
Type:
Small organic molecule
Emp. Form.:
C24H26O6
Mol. Mass.:
410.4596
SMILES:
[#6]-[#8]-c1c(-[#8])cc2oc3cc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c3c(=O)c2c1-[#6]\[#6]=[#6](\[#6])-[#6]
Structure:
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