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Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Ligand
BDBM11318
Substrate
n/a
Meas. Tech.
FabZ Inhibition Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
4.31e+4± 9.2e+3 nM
Comments
extracted
Citation
 McGillick, BE; Kumaran, D; Vieni, C; Swaminathan, S ß-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies. Biochemistry 55:1091-9 (2016) [PubMed]  Article 
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Synonyms:
beta-Hydroxyacyl-acyl carrier protein dehydratase (FtFabZ)
Type:
Protein
Mol. Mass.:
18151.57
Organism:
Francisella tularensis
Description:
n/a
Residue:
163
Sequence:
MSQFNQNNKQIDVMGIRKILPHRYPFALLDKIVDWSVEDRTIVAQKNVTINEDFFNGHFPDFPVMPGVLIVEAMAQATAILGELMAETLFAHVVEKAGGGRRTFMLAGIDKVRVKRPVVPGDVLVIESRMVKQKNIICTAESVAKVDGQIVCSAELMAAYKDY
  
Inhibitor
Name:
BDBM11318
Synonyms:
1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione | 1,3,8-trihydroxy-6-methylanthra-9,10-quinone | CHEMBL289277 | Emodin | US20230364057, Compound 242 | med.21724, Compound 24
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
Structure:
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