Reaction Details Report a problem with these data
Target
Prostaglandin E synthase 2
Ligand
BDBM181918
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
6.8±n/a
IC50
220±n/a nM
Comments
extracted
Citation
 Bylund, J; Ek, ME; Gravenfors, Y; Nordvall, G; Minidis, A; Vallin, KS; Viklund, J; Holenz, J; Von Berg, S; Sohn, D Bis-(sulfonylamino) derivatives for use in therapy US Patent  US9145380 Publication Date 9/29/2015 
Target
Name:
Prostaglandin E synthase 2
Synonyms:
C9orf15 | PGES2 | PGES2_HUMAN | PTGES2
Type:
Enzyme
Mol. Mass.:
41955.21
Organism:
Homo sapiens (Human)
Description:
Q9H7Z7
Residue:
377
Sequence:
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
  
Inhibitor
Name:
BDBM181918
Synonyms:
US9145380, 121
Type:
Small organic molecule
Emp. Form.:
C19H15F3N2O5S2
Mol. Mass.:
472.458
SMILES:
NS(=O)(=O)c1ccccc1NS(=O)(=O)c1cccc(c1)-c1cccc(OC(F)(F)F)c1
Structure:
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