Reaction Details Report a problem with these data
Target
Prostaglandin E synthase 2
Ligand
BDBM182005
Substrate
n/a
Meas. Tech.
Biochemical Assay
pH
6.8±n/a
IC50
55±n/a nM
Comments
extracted
Citation
 Bylund, J; Ek, ME; Gravenfors, Y; Nordvall, G; Minidis, A; Vallin, KS; Viklund, J; Holenz, J; Von Berg, S; Sohn, D Bis-(sulfonylamino) derivatives for use in therapy US Patent  US9145380 Publication Date 9/29/2015 
Target
Name:
Prostaglandin E synthase 2
Synonyms:
C9orf15 | PGES2 | PGES2_HUMAN | PTGES2
Type:
Enzyme
Mol. Mass.:
41955.21
Organism:
Homo sapiens (Human)
Description:
Q9H7Z7
Residue:
377
Sequence:
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
  
Inhibitor
Name:
BDBM182005
Synonyms:
US9145380, 208
Type:
Small organic molecule
Emp. Form.:
C20H22N2O4S2
Mol. Mass.:
418.53
SMILES:
CC(C)(C)C#Cc1ccc(\C=C\S(=O)(=O)Nc2ccccc2S(N)(=O)=O)cc1
Structure:
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