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Target
Tyrosine-protein kinase SYK
Ligand
BDBM182297
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1±n/a nM
Comments
extracted
Citation
 Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent  US9145391 Publication Date 9/29/2015 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM182297
Synonyms:
US9145391, 12-1
Type:
Small organic molecule
Emp. Form.:
C26H28F2N4O3
Mol. Mass.:
482.5223
SMILES:
Cc1cc(Nc2cc(ccn2)C(F)F)nc(c1)-c1ccc(C[C@@H](O)[C@H]2CC[C@@H](CC2)C(O)=O)nc1 |wU:22.24,24.25,wD:27.32,(5.1,-6.89,;3.77,-6.12,;2.44,-6.89,;1.1,-6.12,;-.23,-6.89,;-.23,-8.43,;1.1,-9.2,;1.1,-10.74,;-.23,-11.51,;-1.57,-10.74,;-1.57,-9.2,;2.44,-11.51,;3.77,-10.74,;2.44,-13.05,;1.1,-4.58,;2.44,-3.81,;3.77,-4.58,;2.44,-2.27,;1.1,-1.5,;1.1,.04,;2.44,.81,;2.44,2.35,;1.1,3.12,;-.23,2.35,;1.1,4.66,;-.23,5.43,;-.23,6.97,;1.1,7.74,;2.44,6.97,;2.44,5.43,;1.1,9.28,;-.23,10.05,;2.44,10.05,;3.77,.04,;3.77,-1.5,)|
Structure:
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