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Target
Insulin receptor [964-1370]
Ligand
BDBM184382
Substrate
n/a
Meas. Tech.
DELFIA Assay
pH
7.4±n/a
IC50
0.1±n/a nM
Comments
extracted
Citation
 Treu, M 5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors US Patent  US9150578 Publication Date 10/6/2015 
Target
Name:
Insulin receptor [964-1370]
Synonyms:
INSR | INSR_HUMAN | Insulin-like growth factor 1 receptor (aa 964-1370)
Type:
n/a
Mol. Mass.:
46101.87
Organism:
Homo sapiens (Human)
Description:
P06213[964-1370]
Residue:
407
Sequence:
FVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKN
  
Inhibitor
Name:
BDBM184382
Synonyms:
US9150578, I-030
Type:
Small organic molecule
Emp. Form.:
C32H39N11O
Mol. Mass.:
593.7252
SMILES:
COCCN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccc(cc3)-c3cnn(C)c3)n2)CC1
Structure:
Search PDB for entries with ligand similarity: