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Target
Baculoviral IAP repeat-containing protein 2
Ligand
BDBM184607
Substrate
n/a
Meas. Tech.
In Vitro Competitive Displacement Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
505±n/a nM
Comments
extracted
Citation
 Buck, IM; Chessari, G; Howard, S; Rees, DC; Woolford, AJ Bicyclic heterocycle compounds and their uses in therapy US Patent  US9155743 Publication Date 10/13/2015 
Target
Name:
Baculoviral IAP repeat-containing protein 2
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48
Type:
Protein
Mol. Mass.:
69900.47
Organism:
Homo sapiens (Human)
Description:
Q13490
Residue:
618
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
  
Inhibitor
Name:
BDBM184607
Synonyms:
US9155743, 37
Type:
Small organic molecule
Emp. Form.:
C23H28ClN5O2
Mol. Mass.:
441.954
SMILES:
CN[C@@H](C)C(=O)Nc1ccc2N(C(=O)N(Cc2n1)C(C)C1CCC1)c1cccc(Cl)c1 |r|
Structure:
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