Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM187012
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2.6±n/a nM
Comments
extracted
Citation
 Bair, KW; Baumeister, T; Buckmelter, AJ; Clodfelter, KH; Han, B; Lin, J; Reynolds, DJ; Smith, CC; Wang, Z; Zheng, X Compounds and compositions for the inhibition of NAMPT US Patent  US9169209 Publication Date 10/27/2015 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM187012
Synonyms:
US9169209, Table 3, Compound 44
Type:
Small organic molecule
Emp. Form.:
C20H20N4O3S
Mol. Mass.:
396.463
SMILES:
CCCn1cc(cn1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Structure:
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