Reaction Details Report a problem with these data
Target
Sepiapterin reductase
Ligand
BDBM187251
Substrate
n/a
Meas. Tech.
Chromogenic assay
pH
6.5±n/a
Temperature
310.15±n/a K
IC50
360±n/a nM
Comments
extracted
Citation
 Blagg, J Sepiapterin reductase inhibitors for the treatment of pain US Patent  US9169234 Publication Date 10/27/2015 
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM187251
Synonyms:
US9169234, 2
Type:
Small organic molecule
Emp. Form.:
C14H16N2O2
Mol. Mass.:
244.289
SMILES:
Oc1ccc2[nH]cc(CCNC(=O)C3CC3)c2c1
Structure:
Search PDB for entries with ligand similarity: