Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM187312
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
8±n/a
IC50
<10±n/a nM
Comments
extracted
Citation
 Tora, GO; Finlay, H; Hu, CH; Jiang, J; Johnson, JA; Kim, S; Lloyd, J; Parkhurst, B; Pi, Z; Qiao, JX; Wang, TC Ketone linked benzothiazole inhibitors of endothelial lipase US Patent  US9169240 Publication Date 10/27/2015 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM187312
Synonyms:
US9169240, 51
Type:
Small organic molecule
Emp. Form.:
C21H16N6O4S
Mol. Mass.:
448.455
SMILES:
NC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(NC2CCNC2=O)o1
Structure:
Search PDB for entries with ligand similarity: