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Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM50438865
Substrate
n/a
Meas. Tech.
Recombinant TDP2 Assay
pH
7.5±n/a
IC50
>1.11e+5±n/a nM
Comments
extracted
Citation
 Marchand, C; Abdelmalak, M; Kankanala, J; Huang, SY; Kiselev, E; Fesen, K; Kurahashi, K; Sasanuma, H; Takeda, S; Aihara, H; Wang, Z; Pommier, Y Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. ACS Chem Biol 11:1925-33 (2016) [PubMed]  Article 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
TYDP2_MOUSE | Tdp2 | Ttrap | Tyrosyl-DNA phosphodiesterase 2 (mTDP2 WT)
Type:
Protein
Mol. Mass.:
41027.02
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
370
Sequence:
MASGSSSDAAEPAGPAGRAASAPEAAQAEEDRVKRRRLQCLGFALVGGCDPTMVPSVLRENDWQTQKALSAYFELPENDQGWPRQPPTSFKSEAYVDLTNEDANDTTILEASPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
  
Inhibitor
Name:
BDBM50438865
Synonyms:
2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-carbonitrile (3) | CHEMBL2420506
Type:
Small organic molecule
Emp. Form.:
C18H10N4O2
Mol. Mass.:
314.2976
SMILES:
O=c1nc2n(-c3ccccc3)c3cc(ccc3cc2c(=O)[nH]1)C#N
Structure:
Search PDB for entries with ligand similarity: