Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM190574
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
310.15±n/a K
IC50
7.1±n/a nM
Comments
extracted
Citation
 Maruyama, T; Okada, H; Konemura, T Therapeutic agent for urinary excretion disorder US Patent  US9181187 Publication Date 11/10/2015 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_MOUSE | PGE receptor, EP1 subtype | Prostaglandin E1 | Prostaglandin E2 receptor EP1 subtype | Prostanoid EP1 receptor | Ptger1 | Ptgerep1
Type:
G-protein coupled receptor
Mol. Mass.:
43000.62
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
405
Sequence:
MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM190574
Synonyms:
US9181187, Compound L
Type:
Small organic molecule
Emp. Form.:
C24H26N4O5S2
Mol. Mass.:
514.617
SMILES:
CC(C)N(c1cc(C)c(C)cc1OCc1ccc(cc1)-c1noc(=O)[nH]1)S(=O)(=O)c1nc(C)cs1
Structure:
Search PDB for entries with ligand similarity: