Reaction Details
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Glutaminyl-peptide cyclotransferase-like protein
Ligand
BDBM190690
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
Temperature
303.15±n/a K
Ki
10±n/a nM
IC50
80±n/a nM
Comments
extracted
Citation
Heiser, U; Ramsbeck, D; Hoffmann, T; Boehme, L; Demuth, H Inhibitors of glutaminyl cyclase US Patent US9181233 Publication Date 11/10/2015 More Info.:
Target
Name:
Glutaminyl-peptide cyclotransferase-like protein
Synonyms:
Glutaminyl Cyclase | Glutaminyl-peptide cyclotransferase-like protein (QC) | QPCTL | QPCTL_HUMAN
Type:
Protein
Mol. Mass.:
42941.16
Organism:
Homo sapiens (Human)
Description:
Q9NXS2
Residue:
382
Sequence:
MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
Inhibitor
Name:
BDBM190690
Synonyms:
US9181233, 67
Type:
Small organic molecule
Emp. Form.:
C18H16N4O2S2
Mol. Mass.:
384.475
SMILES:
COc1ccc(SCc2nnc(s2)-c2ccc3[nH]cnc3c2)cc1OC
Structure:
