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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
Ligand
BDBM192507
Substrate
n/a
Meas. Tech.
AMPK Activation Assay
pH
7±n/a
EC50
108±n/a nM
Citation
 Wagner, H; Himmelsbach, F Azabenzimidazole derivatives US Patent  US9187477 Publication Date 11/17/2015 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:
AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Type:
Protein
Mol. Mass.:
64023.62
Organism:
Homo sapiens (Human)
Description:
Q13131
Residue:
559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
  
Inhibitor
Name:
BDBM192507
Synonyms:
US9187477, 3
Type:
Small organic molecule
Emp. Form.:
C30H35ClN4O6
Mol. Mass.:
583.075
SMILES:
O[C@@H]1COC2[C@@H](COC12)Oc1nc2cc(Cl)c(nc2[nH]1)-c1ccc(cc1)[C@@H]1CC[C@@H](CC1)NC(=O)OC1CCCC1 |r,wU:26.30,5.10,1.0,29.37,(12.46,-7.02,;11.69,-5.69,;12.17,-4.23,;10.92,-3.32,;9.68,-4.23,;8.14,-4.23,;7.66,-5.69,;8.91,-6.6,;10.15,-5.69,;7.36,-2.89,;5.83,-2.89,;4.92,-4.14,;3.46,-3.66,;2.12,-4.43,;.79,-3.66,;-.55,-4.43,;.79,-2.12,;2.12,-1.35,;3.46,-2.12,;4.92,-1.65,;-.55,-1.35,;-.55,.19,;-1.88,.96,;-3.21,.19,;-3.21,-1.35,;-1.88,-2.12,;-4.55,.96,;-4.55,2.5,;-5.88,3.27,;-7.21,2.5,;-7.21,.96,;-5.88,.19,;-8.55,3.27,;-9.88,2.5,;-9.88,.96,;-11.21,3.27,;-11.21,4.81,;-9.97,5.71,;-10.45,7.18,;-11.99,7.18,;-12.46,5.71,)|
Structure:
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