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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
Ligand
BDBM192509
Substrate
n/a
Meas. Tech.
AMPK Activation Assay
pH
7±n/a
EC50
119±n/a nM
Citation
 Wagner, H; Himmelsbach, F Azabenzimidazole derivatives US Patent  US9187477 Publication Date 11/17/2015 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:
AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Type:
Protein
Mol. Mass.:
64023.62
Organism:
Homo sapiens (Human)
Description:
Q13131
Residue:
559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
  
Inhibitor
Name:
BDBM192509
Synonyms:
US9187477, 5
Type:
Small organic molecule
Emp. Form.:
C30H35ClN4O7
Mol. Mass.:
599.075
SMILES:
O[C@@H]1COC2[C@@H](COC12)Oc1nc2cc(Cl)c(nc2[nH]1)-c1ccc(cc1)[C@@H]1CC[C@@H](CC1)NC(=O)OC1CCOCC1 |r,wU:26.30,5.10,1.0,29.37,(12.5,-7.38,;11.73,-6.05,;12.21,-4.58,;10.96,-3.68,;9.72,-4.58,;8.18,-4.58,;7.7,-6.05,;8.95,-6.95,;10.19,-6.05,;7.41,-3.25,;5.87,-3.25,;4.96,-4.49,;3.5,-4.02,;2.17,-4.79,;.83,-4.02,;-.5,-4.79,;.83,-2.48,;2.17,-1.71,;3.5,-2.48,;4.96,-2,;-.5,-1.71,;-.5,-.17,;-1.84,.6,;-3.17,-.17,;-3.17,-1.71,;-1.84,-2.48,;-4.5,.6,;-4.5,2.14,;-5.84,2.91,;-7.17,2.14,;-7.17,.6,;-5.84,-.17,;-8.5,2.91,;-9.84,2.14,;-9.84,.6,;-11.17,2.91,;-11.17,4.45,;-12.5,5.22,;-12.5,6.76,;-11.17,7.53,;-9.84,6.76,;-9.84,5.22,)|
Structure:
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