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Target
Mannosyl-oligosaccharide glucosidase
Ligand
BDBM193874
Substrate
n/a
Meas. Tech.
α-Glucosidase inhibition assay
pH
6.8±n/a
IC50
1.4117e+5± 4.02e+3 nM
Comments
extracted
Citation
 Özil, M; Emirik, M; Etlik, SY; Ülker, S; Kahveci, B A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies. Bioorg Chem 68:226-35 (2016) [PubMed]  Article 
Target
Name:
Mannosyl-oligosaccharide glucosidase
Synonyms:
CWH41 | CWH41_YEAST | GLS1 | alpha-Glucosidase (α-glucosidase)
Type:
Protein
Mol. Mass.:
96475.51
Organism:
Saccharomyces cerevisiae (Yeast)
Description:
n/a
Residue:
833
Sequence:
MLISKSKMFKTFWILTSIVLLASATVDISKLQEFEEYQKFTNESLLWAPYRSNCYFGMRPRYVHESPLIMGIMWFNSLSQDGLHSLRHFATPQDKLQKYGWEVYDPRIGGKEVFIDEKNNLNLTVYFVKSKNGENWSVRVQGEPLDPKRPSTASVVLYFSQNGGEIDGKSSLAMIGHDGPNDMKFFGYSKELGEYHLTVKDNFGHYFKNPEYETMEVAPGSDCSKTSHLSLQIPDKEVWKARDVFQSLVSDSIRDILEKEETKQRPADLIPSVLTIRNLYNFNPGNFHYIQKTFDLTKKDGFQFDITYNKLGTTQSISTREQVTELITWSLNEINARFDKQFSFGEGPDSIESVEVKRRFALETLSNLLGGIGYFYGNQLIDRETEFDESQFTEIKLLNAKEEGPFELFTSVPSRGFFPRGFYWDEGFHLLQIMEYDFDLAFEILASWFEMIEDDSGWIAREIILGNEARSKVPQEFQVQNPNIANPPTLLLAFSEMLSRAIENIGDFNSDSYHQVMFNSRTAKFMTNNLEANPGLLTEYAKKIYPKLLKHYNWFRKSQTGLIDEYEEILEDEGIWDKIHKNEVYRWVGRTFTHCLPSGMDDYPRAQPPDVAELNVDALAWVGVMTRSMKQIAHVLKLTQDEQRYAQIEQEVVENLDLLHWSENDNCYCDISIDPEDDEIREFVCHEGYVSVLPFALKLIPKNSPKLEKVVALMSDPEKIFSDYGLLSLSRQDDYFGKDENYWRGPIWMNINYLCLDAMRYYYPEVILDVAGEASNAKKLYQSLKINLSNNIYKVWEEQGYCYENYSPIDGHGTGAEHFTGWTALVVNILGRF
  
Inhibitor
Name:
BDBM193874
Synonyms:
2-{[2-(2,4-Dichlorobenzyl)-1H-benzimidazol-1-yl]acetyl}-N-phenylhydrazinecarbothioamide (6a)
Type:
Small organic molecule
Emp. Form.:
C23H19Cl2N5OS
Mol. Mass.:
484.401
SMILES:
Clc1ccc(Cc2nc3ccccc3n2CC(=O)NNC(=S)Nc2ccccc2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: