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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM194963
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
4±n/a nM
Comments
extracted
Citation
 Ding, F; Dong, S; Frie, J; Gu, X; Jiang, J; Pasternak, A; Tang, H; Wu, Z; Yu, Y; Suzuki, T Inhibitors of the renal outer medullary potassium channel US Patent  US9206198 Publication Date 12/8/2015 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM194963
Synonyms:
US9206198, 18
Type:
Small organic molecule
Emp. Form.:
C28H34N2O6
Mol. Mass.:
494.5794
SMILES:
CO[C@@H](CN1CC2CCC(C1)CC1(CCN(C3=CC(=O)OC3)C1=O)C2)c1ccc2C(=O)OCc2c1C |r,t:17,TLB:22:12:7.8:5.10.4,THB:3:4:7.8:11.24.12|
Structure:
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