Reaction Details Report a problem with these data
Target
Androgen-dependent TFPI-regulating protein
Ligand
BDBM195604
Substrate
n/a
Meas. Tech.
Gel-based ABPP Assay
IC50
8.5e+3± 3.0e+3 nM
Citation
 Parsons, WH; Kolar, MJ; Kamat, SS; Cognetta, AB; Hulce, JJ; Saez, E; Kahn, BB; Saghatelian, A; Cravatt, BF AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol 12:367-72 (2016) [PubMed]  Article 
Target
Name:
Androgen-dependent TFPI-regulating protein
Synonyms:
ADTRP | ADTRP_HUMAN | Androgen-dependent TFPI-regulating protein (ADTRP) | C6orf105
Type:
Protein
Mol. Mass.:
26858.19
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
230
Sequence:
MTKTSTCIYHFLVLSWYTFLNYYISQEGKDEVKPKILANGARWKYMTLLNLLLQTIFYGVTCLDDVLKRTKGGKDIKFLTAFRDLLFTTLAFPVSTFVFLAFWILFLYNRDLIYPKVLDTVIPVWLNHAMHTFIFPITLAEVVLRPHSYPSKKTGLTLLAAASIAYISRILWLYFETGTWVYPVFAKLSLLGLAAFFSLSYVFIASIYLLGEKLNHWKWGDMRQPRKKRK
  
Inhibitor
Name:
BDBM195604
Synonyms:
JJH260
Type:
Small organic molecule
Emp. Form.:
C29H34ClN5O5
Mol. Mass.:
568.064
SMILES:
CN(C)c1ccc(cc1)C(=O)N1CCN2C(C1)C(=O)N(OC(=O)N1CCC(CCc3ccc(Cl)cc3)CC1)C2=O
Structure:
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