Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM25150
Substrate
n/a
Meas. Tech.
In vitro HDACs Inhibition Fluorescence Assay
IC50
353±49 nM
Citation
 Li, J; Li, X; Wang, X; Hou, J; Zang, J; Gao, S; Xu, W; Zhang, Y PXD101 analogs with L-phenylglycine-containing branched cap as histone deacetylase inhibitors. Chem Biol Drug Des 88:574-84 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM25150
Synonyms:
(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide | Belinosta | Belinostat | PXD-101 | PXD101
Type:
Small organic molecule
Emp. Form.:
C15H14N2O4S
Mol. Mass.:
318.348
SMILES:
ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: