Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM199180
Substrate
n/a
Meas. Tech.
PTP pNPP Assay
pH
7±n/a
Temperature
298.15±n/a K
Ki
>1000±0.0 nM
Comments
extracted
Citation
 Zhang, Z; Zhang, S Inhibitors of protein tyrosine phosphatases US Patent  US9217012 Publication Date 12/22/2015 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM199180
Synonyms:
US9217012, 10
Type:
Small organic molecule
Emp. Form.:
C46H62F2N5O9P
Mol. Mass.:
897.9831
SMILES:
CCc1ccc(cc1)C(=O)NCCCCC(NC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)COC1CC(C)CCC1C(C)C)C(N)=O
Structure:
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