Reaction Details
Report a problem with these data
Report a problem with these dataTarget
WD repeat-containing protein 5 [24-334]
Ligand
BDBM200716
Substrate
n/a
Meas. Tech.
Binding Assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
>1000±n/a nM
Comments
extracted
Citation
Wang, S; Karatas, H; Dou, Y; Townsend, E; Bernard, D Inhibition of WDR5 interaction with its binding partners US Patent US9233086 Publication Date 1/12/2016 More Info.:
Target
Name:
WD repeat-containing protein 5 [24-334]
Synonyms:
BIG3 | WD repeat-containing protein 5 (WDR5) | WDR5 | WDR5_HUMAN
Type:
n/a
Mol. Mass.:
34198.55
Organism:
Homo sapiens (Human)
Description:
N-terminal His-tagged WDR5Delta23 (residues 24-334)
Residue:
311
Sequence:
TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Inhibitor
Name:
BDBM200716
Synonyms:
US9233086, 10E
Type:
Small organic molecule
Emp. Form.:
C25H39N7O4
Mol. Mass.:
501.6217
SMILES:
CCC(CC)(NC(=O)c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(N)=O |r|
Structure:
