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Target
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Ligand
BDBM202717
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
0.508±n/a nM
Comments
extracted
Citation
 Barsanti, PA; Burger, M; Lou, Y; Nishiguchi, G; Polyakov, V; Ramurthy, S; Rico, A; Setti, L; Smith, A; Taft, B; Tanner, H; DiPesa, A; Yusuff, N Biaryl amide compounds as kinase inhibitors US Patent  US9242969 Publication Date 1/26/2016 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [1-324]
Synonyms:
C-Raf TR (aa 1-324) | Proto-oncogene C-Raf (C-Raf TR) | RAF | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
36996.69
Organism:
Homo sapiens (Human)
Description:
P04049 (1-324)
Residue:
324
Sequence:
QEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM202717
Synonyms:
US10245267, Example 63 | US10709712, Example 63 | US9242969, 63 | US9694016, 63
Type:
Small organic molecule
Emp. Form.:
C24H22F3N3O2
Mol. Mass.:
441.4456
SMILES:
Cc1ccc(cc1-c1ccnc(c1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F
Structure:
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