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Target
Mitogen-activated protein kinase 1
Ligand
BDBM204272
Substrate
n/a
Meas. Tech.
ERK2 (20 pM) Kinase Assay
pH
7.5±n/a
IC50
0.0175±n/a nM
Comments
extracted
Citation
 Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent  US9242996 Publication Date 1/26/2016 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM204272
Synonyms:
US9242996, 346
Type:
Small organic molecule
Emp. Form.:
C25H26FIN4O3
Mol. Mass.:
576.4018
SMILES:
Nc1ncc(nc1-c1ccc(C(=O)N[C@H](CO)c2cccc(I)c2)c(F)c1)[C@H]1CC[C@H](O)CC1 |r,wU:30.33,wD:27.29,14.14,(-6,3.85,;-6,2.31,;-7.34,1.54,;-7.34,,;-6,-.77,;-4.67,,;-4.67,1.54,;-3.33,2.31,;-2,1.54,;-.67,2.31,;-.67,3.85,;.67,4.62,;.67,6.16,;2,3.85,;3.33,4.62,;3.33,6.16,;4.67,6.93,;4.67,3.85,;6,4.62,;7.34,3.85,;7.34,2.31,;6,1.54,;6,,;4.67,2.31,;-2,4.62,;-2,6.16,;-3.33,3.85,;-6,-2.31,;-7.34,-3.08,;-7.34,-4.62,;-6,-5.39,;-6,-6.93,;-4.67,-4.62,;-4.67,-3.08,)|
Structure:
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