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Target
Bromodomain testis-specific protein [21-137,251-382]
Ligand
BDBM205431
Substrate
n/a
Meas. Tech.
Bromodomains Assay for DiscoveRx Gene Symbol
Ki
0.42±0.0 nM
Citation
 Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol 12:1089-1096 (2016) [PubMed]  Article 
Target
Name:
Bromodomain testis-specific protein [21-137,251-382]
Synonyms:
BRDT_HUMAN | BRDT | Bromodomain testis (1, 2) (BRDT(1,2))
Type:
n/a
Mol. Mass.:
29512.81
Organism:
Human
Description:
Q58F21 (BRDT, 21-137 and 251-382)
Residue:
249
Sequence:
NTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVE
  
Inhibitor
Name:
BDBM205431
Synonyms:
(6S+2S)-PEG1 (7)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCOCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |r,c:6,36|
Structure:
Search PDB for entries with ligand similarity: