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Target
E3 ubiquitin-protein ligase Mdm2 [1-118,T47W]
Ligand
BDBM207985
Substrate
n/a
Meas. Tech.
Microscale Thermophoresis (MT) Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Kd
1.5e+3± 4e+2 nM
Comments
extracted
Citation
 Surmiak, E; Twarda-Clapa, A; Zak, KM; Musielak, B; Tomala, MD; Kubica, K; Grudnik, P; Madej, M; Jablonski, M; Potempa, J; Kalinowska-Tluscik, J; Dömling, A; Dubin, G; Holak, TA A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction. ACS Chem Biol 11:3310-3318 (2016) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [1-118,T47W]
Synonyms:
MDM2 | MDM2_HUMAN
Type:
Protein
Mol. Mass.:
13556.52
Organism:
Homo sapiens (Human)
Description:
Mdm2 truncation (1-118 aa) with mutation at T47W
Residue:
118
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDWYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDS
  
Inhibitor
Name:
BDBM207985
Synonyms:
4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-5-hydroxy-1,5-dihydro-2H-furan-2-one (2b)
Type:
Small organic molecule
Emp. Form.:
C26H18Cl3NO3
Mol. Mass.:
498.785
SMILES:
OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12 |c:14|
Structure:
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