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Target
Kappa-type opioid receptor
Ligand
BDBM209922
Substrate
n/a
Meas. Tech.
[35S]GTPγS Coupling Assay
IC50
0.44±0.15 nM
Citation
 Schmid, CL; Streicher, JM; Groer, CE; Munro, TA; Zhou, L; Bohn, LM Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at kappa-opioid receptors in striatal neurons. J Biol Chem 288:22387-98 (2013) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM209922
Synonyms:
6'-Guanidinonaltrindole (6'-GNTI)
Type:
Small organic molecule
Emp. Form.:
C27H29N5O3
Mol. Mass.:
471.5509
SMILES:
NC(N)=Nc1ccc2c3C[C@@]4(O)[C@@H]5Cc6ccc(O)c7O[C@@H](c3[nH]c2c1)[C@]4(CCN5CC1CC1)c67 |wU:10.10,wD:21.20,12.33,26.39,TLB:11:10:29.27.28:34.13.14,9:10:29.27.28:34.13.14,(16.68,-7.05,;16,-5.67,;16.85,-4.39,;14.46,-5.57,;13.77,-4.19,;14.64,-2.88,;13.92,-1.49,;12.36,-1.42,;11.42,-.24,;11.74,1.24,;10.68,2.32,;12.2,2.58,;10.68,3.86,;9.35,4.63,;8.01,3.86,;6.63,4.68,;5.24,3.89,;5.24,2.28,;3.91,1.51,;6.63,1.49,;7.25,.09,;8.78,.12,;10,-.77,;10.08,-2.28,;11.53,-2.68,;12.21,-4.09,;9.35,1.55,;9.03,2.12,;8.9,3.34,;10.03,3.84,;10.35,5.35,;9.2,6.38,;8.73,7.84,;7.7,6.7,;8.01,2.32,)|
Structure:
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