Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM119408
Substrate
n/a
Meas. Tech.
Pim Kinase Binding Activity
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
0.735±n/a nM
Comments
extracted
Citation
 Wang, X Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9573943 Publication Date 2/21/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM119408
Synonyms:
US8669361, 369 | US9573943, Example 369
Type:
Small organic molecule
Emp. Form.:
C20H22F2N6OS
Mol. Mass.:
432.49
SMILES:
Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CCC(N)CC1 |(-5.88,3.66,;-5.11,2.33,;-6.01,1.08,;-5.11,-.17,;-3.64,.31,;-2.31,-.46,;-2.31,-2,;-3.64,-2.77,;-.98,-2.77,;.49,-2.29,;1.39,-3.54,;.49,-4.79,;-.98,-4.31,;-2.31,-5.08,;2.93,-3.54,;3.7,-2.21,;2.93,-.87,;5.24,-2.21,;6.01,-3.54,;5.24,-4.87,;3.7,-4.87,;2.93,-6.21,;-3.64,1.85,;-2.55,2.94,;-1.07,2.54,;.02,3.63,;-.38,5.12,;.71,6.21,;-1.86,5.52,;-2.95,4.43,)|
Structure:
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