Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM10880
Substrate
n/a
Meas. Tech.
CA Inhibition Assay
Ki
12±0.0 nM
Citation
 Bhatt, A; Mahon, BP; Cruzeiro, VW; Cornelio, B; Laronze-Cochard, M; Ceruso, M; Sapi, J; Rance, GA; Khlobystov, AN; Fontana, A; Roitberg, A; Supuran, CT; McKenna, R Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity. Chembiochem 18:213-222 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CAH2_HUMAN | CA2 | CA-II | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM10880
Synonyms:
Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolamide | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Acetazolamide, AZA | AZA | Acetazolamide, 5 | Sulfonamide, 1 | Acerazolamide, AAZ | Acetazolamide, AZM | sulfonamide 1 | Acetazolamide (AAZ) | Acetazolamide (AZM) | AZM acetazolamide | Acetazolamide (AZA) | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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