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Target
Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A]
Ligand
BDBM210935
Substrate
n/a
Meas. Tech.
CA Inhibition Assay
Ki
0.2±0.0 nM
Citation
 Bhatt, A; Mahon, BP; Cruzeiro, VW; Cornelio, B; Laronze-Cochard, M; Ceruso, M; Sapi, J; Rance, GA; Khlobystov, AN; Fontana, A; Roitberg, A; Supuran, CT; McKenna, R Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity. Chembiochem 18:213-222 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A]
Synonyms:
CAH2_HUMAN | CA2 | Carbonic anhydrase 9 (CA IX)
Type:
Protein
Mol. Mass.:
29162.54
Organism:
Human
Description:
Chimeric protein of CA II with 7 mutations (A65S, N67Q, E69T, I91L, F131V, K170E, L204A); 5sZ4, 5SZ5, 5SZ6, 5SZ7
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM210935
Synonyms:
4-(phenyl)-bezenesulfonamide (4a)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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