Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [179-426]
Ligand
BDBM102348
Substrate
n/a
Meas. Tech.
Activity Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
14000±n/a nM
Comments
extracted
Citation
 Shalwitz, R; Gardner, JH Methods for increasing the stabilization of hypoxia inducible factor-α US Patent  US9278930 Publication Date 3/8/2016 
Target
Name:
Egl nine homolog 1 [179-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2)
Type:
n/a
Mol. Mass.:
27759.84
Organism:
Homo sapiens (Human)
Description:
EGLN-1-179/426
Residue:
248
Sequence:
LRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM102348
Synonyms:
US10562854, No. A41 | US8536181, A41 | US9278930, A41
Type:
Small organic molecule
Emp. Form.:
C22H28ClN3O4
Mol. Mass.:
433.928
SMILES:
CC(C)(C)OC(=O)N1CCN(Cc2ccn(Cc3ccc(Cl)cc3)c(=O)c2O)CC1
Structure:
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