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Target
Tyrosine-protein kinase ITK/TSK [357-620,Y512E]
Ligand
BDBM213226
Substrate
n/a
Meas. Tech.
LanthaScreen Kinase Binding Assay
IC50
40±0 nM
Citation
 Harling, JD; Deakin, AM; Campos, S; Grimley, R; Chaudry, L; Nye, C; Polyakova, O; Bessant, CM; Barton, N; Somers, D; Barrett, J; Graves, RH; Hanns, L; Kerr, WJ; Solari, R Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. J Biol Chem 288:28195-206 (2013) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ITK/TSK [357-620,Y512E]
Synonyms:
EMT | ITK | ITK_HUMAN | Interlukin-2-inducible tyrosine kinase (Itk) | LYK
Type:
Enzyme
Mol. Mass.:
30027.99
Organism:
Homo sapiens (Human)
Description:
Human Itk truncation (357-620 aa) with Y512E mutation
Residue:
264
Sequence:
VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQETSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
  
Inhibitor
Name:
BDBM213226
Synonyms:
N-{(3S)-1-[(2E)-2-Butenoyl]-3-pyrrolidinyl}-4-{[cis-2,6-dimethyl-4-morpholinyl]methyl}-N'-[1,3]thiazolo[5,4-b]pyridin-2-yl-2,6-pyridinediamine (16)
Type:
Small organic molecule
Emp. Form.:
C26H33N7O2S
Mol. Mass.:
507.651
SMILES:
C\C=C\C(=O)N1CC[C@@H](C1)Nc1cc(CN2C[C@H](C)O[C@H](C)C2)cc(Nc2nc3cccnc3s2)n1 |r|
Structure:
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