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Target
Catenin beta-1 [138-686]/Transcription factor 4 [7-51]
Ligand
BDBM32102
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
3650±680 nM
Comments
extracted
Citation
 Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9284299 Publication Date 3/15/2016 
Target
Name:
Catenin beta-1 [138-686]/Transcription factor 4 [7-51]
Synonyms:
Beta-catenin/Tcf4
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Homo sapiens (Human)
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Component 2
Name:
Transcription factor 4 [7-51]
Synonyms:
BHLHB19 | ITF2 | ITF2_HUMAN | SEF2 | TCF4 | Transcription factor 4 (TCF4)
Type:
Enzyme
Mol. Mass.:
4569.48
Organism:
Homo sapiens (Human)
Description:
Human Tcf4 truncation (7-51 aa)
Residue:
45
Sequence:
MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE
  
Inhibitor
Name:
BDBM32102
Synonyms:
1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone | MLS000087831 | SMR000024051 | US9284299, PKF118-310 | US9738628, Compound PKF118-310 | cid_66541
Type:
Small organic molecule
Emp. Form.:
C7H7N5O2
Mol. Mass.:
193.1628
SMILES:
Cn1ncnc2c1nc(=O)n(C)c2=O
Structure:
Search PDB for entries with ligand similarity: