Reaction Details Report a problem with these data
Target
Cadherin-1 [819-873]/Catenin beta-1 [138-686]
Ligand
BDBM50094484
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
Temperature
298.1500±n/a K
Ki
14390±320 nM
Comments
extracted
Citation
 Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9284299 Publication Date 3/15/2016 
Target
Name:
Cadherin-1 [819-873]/Catenin beta-1 [138-686]
Synonyms:
Beta-catenin/E-cadherin
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB1 | CTNNB
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Human
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Component 2
Name:
Cadherin-1 [819-873]
Synonyms:
Epithelial cadherin (E-cadherin) | CADH1_HUMAN | CDH1 | CDHE | UVO
Type:
Enzyme
Mol. Mass.:
6102.29
Organism:
Human
Description:
Human E-cadherin truncation (819-873 aa)
Residue:
55
Sequence:
DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA
  
Inhibitor
Name:
BDBM50094484
Synonyms:
CHEMBL2323033 | CHEBI:3556 | US9284299, CGP049090 | US9738628, Compound CGP049090
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: