Target
Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686]
Ligand
BDBM213748
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
Temperature
298.15±n/a K
Ki
53850±80 nM
Comments
extracted
Citation
 Ji, HYu, BZhang, MGuo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent  US9284299 Publication Date 3/15/2016 
Target
Name:
Adenomatous polyposis coli protein [1477-1519]/Catenin beta-1 [138-686]
Synonyms:
Beta-catenin/APC-R3
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Catenin beta-1 [138-686]
Synonyms:
Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1
Type:
Protein
Mol. Mass.:
60127.24
Organism:
Homo sapiens (Human)
Description:
aa 138-686
Residue:
549
Sequence:
NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTE
  
Component 2
Name:
Adenomatous polyposis coli protein [1477-1519]
Synonyms:
APC | APC_HUMAN | Adenomatous polyposis coli protein (APC-R3) | DP2.5
Type:
Enzyme
Mol. Mass.:
4662.54
Organism:
Homo sapiens (Human)
Description:
Human APC-R3 truncation (1477-1519 aa)
Residue:
43
Sequence:
QRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKD
  
Inhibitor
Name:
BDBM213748
Synonyms:
US9284299, PKF115-584 | US9738628, Compound PKF115-584
Type:
Small organic molecule
Emp. Form.:
C44H38O14
Mol. Mass.:
790.7641
SMILES:
COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(C[C@@H](C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(C[C@@H](C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O |r|
Structure:
Search PDB for entries with ligand similarity: