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Target
Isoform Tau-F of Microtubule-associated protein tau
Ligand
BDBM214742
Substrate
n/a
Meas. Tech.
Tau Protein Assay
pH
7.4±n/a
IC50
5.8e+2±n/a nM
Comments
extracted
Citation
 Schafer, KN; Cisek, K; Huseby, CJ; Chang, E; Kuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem 288:32599-611 (2013) [PubMed]  Article 
Target
Name:
Isoform Tau-F of Microtubule-associated protein tau
Synonyms:
MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45857.42
Organism:
Homo sapiens (Human)
Description:
P10636-8
Residue:
441
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM214742
Synonyms:
Rhodanines, 30A
Type:
Small organic molecule
Emp. Form.:
C28H17NO7S2
Mol. Mass.:
543.568
SMILES:
[O-]C(=O)Cc1ccc(CN2C(=S)S\C(=C/c3ccc(o3)-c3ccc(cc3)-c3ccc(o3)C([O-])=O)C2=O)cc1
Structure:
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