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Target
Acetylcholinesterase
Ligand
BDBM214684
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1780±n/a nM
Citation
 Chen, R; Feng, L; Zhang, Z; Fang, F; Dong, Q; Li, F; Wang, L; Hua, Y; Yang, S; Wang, P 1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof US Patent  US9284330 Publication Date 3/15/2016 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM214684
Synonyms:
US9284330, S34
Type:
Small organic molecule
Emp. Form.:
C25H28FN3O2
Mol. Mass.:
421.5071
SMILES:
CC1=C(C(c2cccc(F)c2)c2c(N)c3CC(C)(C)CCc3nc2N1)C(=O)OCC=C |t:1|
Structure:
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