Reaction Details Report a problem with these data
Target
Iodotyrosine deiodinase 1 [1-1,32-289]
Ligand
BDBM37633
Substrate
n/a
Meas. Tech.
IYD Binding Assay
Kd
9e+1± 2e+1 nM
Citation
Ingavat, N; Kavran, JM; Sun, Z; Rokita, SE Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase. Biochemistry 56:1130-1139 (2017) [PubMed] Article
More Info.:
Target
Name:
Iodotyrosine deiodinase 1 [1-1,32-289]
Synonyms:
C6orf71 | DEHAL1 | IYD | IYD1_HUMAN | Iodotyrosine deiodinase (IYD)
Type:
Enzyme
Mol. Mass.:
29825.93
Organism:
Homo sapiens (Human)
Description:
Human IYD without its N-terminal transmembrane sequence (2-31 aa)
Residue:
259
Sequence:
MGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
Inhibitor
Name:
BDBM37633
Synonyms:
(2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic acid | (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | (2S)-2-azanyl-3-(3-iodanyl-4-oxidanyl-phenyl)propanoic acid | 3-IODO-L-TYROSINE | 3-Iodo-L-tyrosine (I-Tyr) | MLS000069664 | Monoiodotyrosine | SMR000059143 | cid_439744
Type:
Small organic molecule
Emp. Form.:
C9H10INO3
Mol. Mass.:
307.0851
SMILES:
N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O