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Target
Iodotyrosine deiodinase 1 [1-1,32-289]
Ligand
BDBM217397
Substrate
n/a
Meas. Tech.
IYD Binding Assay
Kd
1.410e+6± 7.0e+4 nM
Citation
 Ingavat, N; Kavran, JM; Sun, Z; Rokita, SE Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase. Biochemistry 56:1130-1139 (2017) [PubMed]  Article 
Target
Name:
Iodotyrosine deiodinase 1 [1-1,32-289]
Synonyms:
C6orf71 | DEHAL1 | IYD | IYD1_HUMAN | Iodotyrosine deiodinase (IYD)
Type:
Enzyme
Mol. Mass.:
29825.93
Organism:
Homo sapiens (Human)
Description:
Human IYD without its N-terminal transmembrane sequence (2-31 aa)
Residue:
259
Sequence:
MGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
  
Inhibitor
Name:
BDBM217397
Synonyms:
2-Iodophenol (2IP)
Type:
Small organic molecule
Emp. Form.:
C6H5IO
Mol. Mass.:
220.0078
SMILES:
Oc1ccccc1I
Structure:
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