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Target
Iodotyrosine deiodinase [1-228]
Ligand
BDBM37633
Substrate
n/a
Meas. Tech.
IYD Binding Assay
Kd
8.2e+3± 5e+2 nM
Citation
 Ingavat, N; Kavran, JM; Sun, Z; Rokita, SE Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase. Biochemistry 56:1130-1139 (2017) [PubMed]  Article 
Target
Name:
Iodotyrosine deiodinase [1-228]
Synonyms:
IYD | IYD_HALH1 | Iodotyrosine deiodinase (IYD)
Type:
Enzyme
Mol. Mass.:
26134.19
Organism:
Haliscomenobacter hydrossis
Description:
F4KU78[1-228]
Residue:
228
Sequence:
MKQKPAFIPYAGAQFEPEEMLSKSAEYYQFMDHRRTVREFSNRAIPLEVIENIVMTASTAPSGAHKQPWTFVVVSDPQIKAKIRQAAEKEEFESYNGRMSNEWLEDLQPFGTDWHKPFLEIAPYLIVVFRKAYDVLPDGTQRKNYYVQESVGIACGFLLAAIHQAGLVALTHTPSPMNFLQKILQRPENERPFLLVPVGYPAEGAMVPDLQRKDKAAVMVVYHHHHHH
  
Inhibitor
Name:
BDBM37633
Synonyms:
(2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic acid | (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | (2S)-2-azanyl-3-(3-iodanyl-4-oxidanyl-phenyl)propanoic acid | 3-IODO-L-TYROSINE | 3-Iodo-L-tyrosine (I-Tyr) | MLS000069664 | Monoiodotyrosine | SMR000059143 | cid_439744
Type:
Small organic molecule
Emp. Form.:
C9H10INO3
Mol. Mass.:
307.0851
SMILES:
N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O
Structure:
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