Reaction Details Report a problem with these data
Target
Iodotyrosine deiodinase [1-228]
Ligand
BDBM217399
Substrate
n/a
Meas. Tech.
IYD Binding Assay
Kd
2.41e+4± 7e+2 nM
Citation
 Ingavat, N; Kavran, JM; Sun, Z; Rokita, SE Active Site Binding Is Not Sufficient for Reductive Deiodination by Iodotyrosine Deiodinase. Biochemistry 56:1130-1139 (2017) [PubMed]  Article 
Target
Name:
Iodotyrosine deiodinase [1-228]
Synonyms:
IYD | IYD_HALH1 | Iodotyrosine deiodinase (IYD)
Type:
Enzyme
Mol. Mass.:
26134.19
Organism:
Haliscomenobacter hydrossis
Description:
F4KU78[1-228]
Residue:
228
Sequence:
MKQKPAFIPYAGAQFEPEEMLSKSAEYYQFMDHRRTVREFSNRAIPLEVIENIVMTASTAPSGAHKQPWTFVVVSDPQIKAKIRQAAEKEEFESYNGRMSNEWLEDLQPFGTDWHKPFLEIAPYLIVVFRKAYDVLPDGTQRKNYYVQESVGIACGFLLAAIHQAGLVALTHTPSPMNFLQKILQRPENERPFLLVPVGYPAEGAMVPDLQRKDKAAVMVVYHHHHHH
  
Inhibitor
Name:
BDBM217399
Synonyms:
4-Hydroxy-3-iodobenzoic acid (2IPCOOH)
Type:
Small organic molecule
Emp. Form.:
C7H5IO3
Mol. Mass.:
264.0173
SMILES:
OC(=O)c1ccc(O)c(I)c1
Structure:
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