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Target
Bcl-2-related protein A1 [1-149]
Ligand
BDBM218795
Substrate
n/a
Meas. Tech.
DELFIA
IC50
8.7±0.1 nM
Citation
 Barile, E; Marconi, GD; De, SK; Baggio, C; Gambini, L; Salem, AF; Kashyap, MK; Castro, JE; Kipps, TJ; Pellecchia, M hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents. ACS Chem Biol 12:444-455 (2017) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1 [1-149]
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl2-related protein A1 (Bfl-1) | GRS | HBPA1
Type:
Protein
Mol. Mass.:
19694.10
Organism:
Homo sapiens (Human)
Description:
Human Bfl-1 truncation (1-149 aa) with N-terminal His-tag.
Residue:
171
Sequence:
MHHHHHHSSGVDLGTENLYFQSMTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFE
  
Inhibitor
Name:
BDBM218795
Synonyms:
130E7 | Ac-λIAQELRRIGDEFNAYYARR-NH2
Type:
Small organic molecule
Emp. Form.:
C110H171ClN36O32
Mol. Mass.:
2545.21
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C(CNC(=O)CCl)NC(C)=O)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r|
Structure:
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