Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1 [45-272,291-390,C386A,C388A]
Ligand
BDBM218815
Substrate
n/a
Meas. Tech.
SPR Screening Assay
Kd
4.15e+4± 6.9e+3 nM
Citation
 Ranganathan, A; Heine, P; Rudling, A; Plückthun, A; Kummer, L; Carlsson, J Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries. ACS Chem Biol 12:735-745 (2017) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1 [45-272,291-390,C386A,C388A]
Synonyms:
NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor type 1 (NTSR1-H4)
Type:
Protein
Mol. Mass.:
36530.59
Organism:
Rattus norvegicus (Rat)
Description:
Rat NTSR1 variant (E45-G390 aa with C386A/C388A mutation) lacking intracellular loop 3 (E273-T290)
Residue:
328
Sequence:
ESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLAALAPG
  
Inhibitor
Name:
BDBM218815
Synonyms:
NTSR-H4 inhibitor, 5
Type:
Small organic molecule
Emp. Form.:
C19H18N4O3
Mol. Mass.:
350.3712
SMILES:
OC(=O)[C@H](Cc1ccncc1)NC(=O)c1cccc(Cn2cccn2)c1 |r|
Structure:
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