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Target
Aldo-keto reductase family 1 member C2
Ligand
BDBM17636
Substrate
n/a
Meas. Tech.
Discontinuous Radiometric Assay
IC50
370±n/a nM
Citation
 Penning, TM; Adeniji, AO; Burns, MC; Winkler, J; Twenter, B Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof US Patent  US9271961 Publication Date 3/1/2016 
Target
Name:
Aldo-keto reductase family 1 member C2
Synonyms:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 3-alpha-Hydroxysteroid Dehydrogenase Type 3 (AKR1C2) | Chlordecone reductase homolog HAKRD | Aldo-keto reductase family 1 member C2 (AK1C2) | 3-alpha-HSD3 | Dihydrodiol dehydrogenase 2 | Type III 3-alpha-hydroxysteroid dehydrogenase | Aldo-keto reductase family 1 member C2 (AK1C2a) | DD-2 | DD/BABP | Dihydrodiol dehydrogenase/bile acid-binding protein | Aldo-keto reductase family 1 member C2 (AKR1C2) | AK1C2_HUMAN | AKR1C2 | DDH2
Type:
Enzyme
Mol. Mass.:
36739.89
Organism:
Human
Description:
n/a
Residue:
323
Sequence:
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
  
Inhibitor
Name:
BDBM17636
Synonyms:
2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid | CHEMBL23588 | Nichisedan | Arlef | Flufenamic acid | US9271961, Flufenamic Acid | US20240002326, Compound Flufenamic acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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