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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM222191
Substrate
n/a
Meas. Tech.
Alkaline Phosphatase Inhibition Assay
pH
9.8±n/a
Temperature
310.15±n/a K
IC50
6.8e+2± 5e+1 nM
Comments
extracted
Citation
 Bhatti, HA; Khatoon, M; Al-Rashida, M; Bano, H; Iqbal, N; Zaib-Un-Nisa, null; Yousuf, S; Khan, KM; Hameed, A; Iqbal, J Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors. Bioorg Chem 71:10-18 (2017) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP)
Type:
Protein
Mol. Mass.:
57195.60
Organism:
Bos taurus (Cattle)
Description:
P09487
Residue:
524
Sequence:
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELNRNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
  
Inhibitor
Name:
BDBM222191
Synonyms:
6-(Dimethylamino)-3-(5'-bromo-2'-hydroxy-3'-methoxyphenyl)-2,3-dihydronaphtho[1,8-de][1,2]thiazine 1,1-dioxide (7m)
Type:
Small organic molecule
Emp. Form.:
C20H19BrN2O4S
Mol. Mass.:
463.345
SMILES:
COc1cc(Br)c(cc1O)C1NS(=O)(=O)c2cccc3c(ccc1c23)N(C)C
Structure:
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